| Amino
acids are the building blocks of proteins. Put very simplistically,
our genes tell our bodies which amino acids to
put into the proteins that we make, and it is the proteins that
make up the significant constituents of our bodies. Myelin Basic
Protein (MBP) is an example of one such protein.
In
order to understand how amino acids are glued together
to make proteins, we must look at the DNA (deoxyribonucleic acid)
that is present in almost all the cells in our bodies.
DNA is built up of many sub-units called neucleotides,
each of which contains a chemical "base". There are only
four different bases and thus only four different nucleotides. The
four bases are adenine (A), thymine (T), cytosine (C) and guanine
(G).
Genes
are sections of DNA, in which the neucleotides are viewed in groups
of three called "triplets" or "codons". Each
codon "codes" for a particular amino acid.
A gene is terminated by a stop code or terminator which is represented
by one of three codons that do not code for amino acids.
There
are 20 different amino acids that are used in animals
(there are others that are used in plants). There are 64 different
codons and most of the 20 amino acids are coded
by more than one triplet.
The
process of synthesizing amino acids from genes
is known as transcription. During transcription, a gene is echoed
from the DNA into a complementary form called ribonucleic acid (RNA).
From
the RNA, amino acids are produced and are joined
with one another with a peptide bond. The resulting sequence of
amino acids is known as peptide string or polypeptide.
Proteins are derived from these polypeptides.
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